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Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
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These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
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Frequently Asked Questions
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Biotin, also known as vitamin B7, is a water-soluble B-vitamin that plays a crucial role in various metabolic processes in the body. It is essential for converting nutrients into energy and is involved in the synthesis of fatty acids, amino acids, and glucose. Biotin is naturally found in a variety of foods, including eggs, nuts, seeds, fish, meat, dairy products, and certain vegetables. While deficiencies are rare due to its abundance in common diets, they can lead to symptoms such as hair loss, skin rashes, and neurological issues.
Many people take biotin supplements believing they can improve hair, skin, and nail health. Although there is some evidence to support the benefits of biotin for hair growth—especially in those with a deficiency—more research is needed to establish its efficacy for those with sufficient levels. The FDA does not regulate dietary supplements as strictly as medications, so it’s crucial to choose high-quality products from reputable manufacturers. Always consult with a healthcare professional before starting any new supplement to ensure it’s appropriate for your specific needs.
When it comes to seeing results from biotin supplements for autoimmune disorders, user reviews indicate a varied timeline. Many users report noticeable improvements in hair loss and strength within a short period. For instance, one reviewer mentioned that their hair shedding stopped within just five days of starting biotin (Read Review). Others, like a user who noticed significant changes after three months, highlighted improvements in hair thickness and nail strength (Read Review).
On the other hand, there are users who experienced slower results. One reviewer shared that after taking the supplement for three months, they hadn’t noticed significant benefits in relation to their autoimmune condition (Read Review). Overall, while some may experience results within a week, others might take longer, suggesting that individual responses can vary significantly based on personal health factors and the specific autoimmune condition being addressed.
While there is some evidence supporting the use of biotin for certain conditions related to autoimmune disorders, the research is circumstantial and focused on specific types of disorders. For instance, studies have shown that patients with biotinidase deficiency may respond positively to biotin supplementation (research IDs: 38991566, 32741581), suggesting its potential in addressing metabolic deficiencies that manifest with neurological symptoms. Additionally, a systematic review indicated some benefits of high-dose biotin in treating multiple sclerosis, particularly in enhancing treatment responses for patients with progressive multiple sclerosis (research IDs: 34332461, 33314801). However, there are caveats, such as possible negative effects on lab results and the need for cautious approaches to treatment (research ID: 34332461).
Based on user reviews, many individuals have reported significant improvements in hair growth and thickness after taking biotin supplements. For instance, one reviewer noted that their hair shedding stopped within just five days of starting biotin, which they credited as a remarkable speed of results (Read Review). Another user mentioned that after three months, they observed not only reduced hair loss but also increased thickness, alongside strengthened nails (Read Review). In addition, users have shared experiences of new hair growth emerging after dealing with hair loss due to various causes, including stress and postpartum changes(Read Review).
Conversely, some users indicate that results may take longer to manifest, which emphasizes the variability of individual responses. For example, one reviewer shared that despite taking the supplement consistently for three months, they did not notice significant benefits regarding their autoimmune condition (Read Review). Other users have found positive changes in their overall health, such as stronger nails and improved skin texture, showing that biotin can have multiple benefits beyond just hair growth (Read Review). Ultimately, while many report positive outcomes, individual experiences can differ widely.
Based on user reviews, many individuals are combining biotin supplements with other vitamins and minerals to maximize their benefits, particularly in managing hair loss due to autoimmune disorders. For example, one review mentioned that combining biotin with omega-3 resulted in fantastic improvements—not only did hair loss cease, but eyelashes also grew longer (Read Review). Another user reported success with biotin and vitamin D3, noting a significant reduction in hair fall and observable growth after just a month of use (Read Review).
Additionally, users have reported that taking biotin alongside vitamin C led to marked improvements in skin conditions related to autoimmune issues, such as seborrhoeic dermatitis (Read Review). Those who experienced limited results with biotin alone discovered more pronounced effects when paired with other supplements, suggesting that multi-supplement strategies may enhance overall effectiveness in combating the symptoms of autoimmune disorders (Read Review). This highlights the potential for synergistic effects by combining biotin with supportive nutrients for better health outcomes.
Based on user reviews, many individuals taking Biotin for treating hair loss associated with autoimmune disorders found significant improvements. A common dosage reported was 10,000 mg, with users observing results within a few weeks. For instance, one user shared that after two weeks of consistent use, their hair loss substantially decreased, while another mentioned impressive regrowth after three months of taking Biotin daily (Read Review)(Read Review). Additionally, one user highlighted stopping hair loss within just five days of beginning the regimen (Read Review).
While many review positive experiences from high dosages, there were mentions of varying results at lower doses, such as one user who took one tablet for three months without observing notable changes (Read Review). It appears that while higher dosages like 10,000 mg have been beneficial for many, individual results may vary greatly. Overall, users frequently encouraged consistent use over several weeks to achieve the best outcomes (Read Review).
References
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2023-258703
- Créange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23:389. doi:10.1186/s12883-023-03440-y
- Thompson ZE, Boyd NK, Khoshnood MM, Santoro JD. Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis. Am J Med Genet A. 2023;191:2868. doi:10.1002/ajmg.a.63376
- Ongaro A, Violatto MB, Casarin E, Pellerani I, Marchini G, et al. The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence. Nanomedicine. 2022;40:102497. doi:10.1016/j.nano.2021.102497
- Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Relat Disord. 2021;55:103159. doi:10.1016/j.msard.2021.103159
- Collongues N, Kuhle J, Tsagkas C, Lamy J, Meyer N, et al. Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003). Brain Behav. 2021;11:e01998. doi:10.1002/brb3.1998
- Mathais S, Moisset X, Pereira B, Taithe F, Ciron J, et al. Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis. Neurotherapeutics. 2021;18:378. doi:10.1007/s13311-020-00926-2
- Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020;42:762. doi:10.1016/j.braindev.2020.07.007
